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Category: NIH

SimBioSys January 19, 2019 NIH, Publications

Essential metabolism for a minimal cell

Abstract: JCVI-syn3A, a robust minimal cell with a 543 kbp genome and 493 genes, provides a versatile platform to study the basics of life. Using the vast amount of experimental information available on its precursor, Mycoplasma mycoides capri, we assembled…

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SimBioSys June 13, 2016 NIH, Publications

Ribosome biogenesis in replicating cells: integration of experiment and theory

Abstract: Ribosomes-the primary macromolecular machines responsible for translating the genetic code into proteins-are complexes of precisely folded RNA and proteins. The ways in which their production and assembly are managed by the living cell is of deep biological importance. Here…

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