Abstract: What would you do if you knew everything about a patient’s tumor? How should a physician make a treatment decision with multi-omics and imaging data at single-cell resolution? We sought to answer these questions by constructing a deterministic, 4-D,…

Abstract: Metabolism is an important regulator of cancer behavior. The extent to which patient-to-patient variability in tumor metabolism influences patient prognosis, however, remains unclear. We addressed this question by developing an approach to simulate cancer metabolism that integrates RNA-seq data…