Background: Nutrient and drug penetration into any solid tumor are critical determinants of the tumor’s response to treatment. They depend on both the density of microvasculature within the tumor microenvironment, as well as the exchange rates of nutrients between the…
Background: Predictive models of the efficacy of different tumor therapies will provide significant enhancements to current standard of care practices. Predicting a given tumor’s growth and treatment response, however, is an intricate process that requires not only an understanding of…
Background: Success of neoadjuvant chemotherapy (NACT) varies by intrinsic subtype of a patient’s breast cancer (e.g., Normal-like, Luminal A/B, HER2-enriched, Triple Negative). The metabolic rate of a given tumor is implicated in response to chemotherapies, as many act by killing…
Abstract: Spatial organization is a characteristic of all cells, achieved in eukaryotic cells by utilizing both membrane-bound and membrane-less organelles. One of the key processes in eukaryotes is RNA splicing, which readies mRNA for translation. This complex and highly dynamical…
Introduction: Intrinsic breast cancer subtypes (e.g., Normal-like, Luminal A/B, HER2-enriched, Triple Negative) vary in their responsiveness to neoadjuvant chemotherapy (NACT) and are associated with differing long-term prognosis. Expression dis-regulation of critical regulatory pathways partially accounts for variance in cancer phenotype…
Introduction: Finalizing the treatment plan to utilize on a cancer patient continues to be a collaborative process between the patient and clinician, often with input from the patient’s family. By referencing the tumor size and location from radiology reports and…
Background: A single neuron cannot think, just as a single hepatocyte cannot filter blood. The functions of the tissues that make up our bodies are emergent, depending on both their constituent cells’ internal biology, as well as how they interact…
Introduction: When considering the use of NACT for breast cancer, healthcare providers and patients must weigh the risks associated with different potential standard of care (SoC) treatment regimens against the likelihood of achieving a desired outcome. The decision of treatment…
Background: Racial disparities in breast cancer incidence and clinical outcome have become increasingly recognized. In particular, African American (AA) patients have higher mortality rates than other racial groups. Research into these racial disparities has primarily focused on socioeconomic determinants, with…
Abstract: JCVI-syn3A, a robust minimal cell with a 543 kbp genome and 493 genes, provides a versatile platform to study the basics of life. Using the vast amount of experimental information available on its precursor, Mycoplasma mycoides capri, we assembled…
SOLUTIONS
- TumorSight Viz
- TumorSight RISK
- PhenoScope
RESOURCES
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